[THAILAND] Laboratoires Activa at the 2024 Vitafoods Asia in Bangkok

Beyond Compliance:
The Pillars of GMP Certification
in Manufacturing Health Supplements

Good Manufacturing Practice (GMP) refers to a set of regulations and guidelines established by regulatory agencies, such as the Food and Drug Administration (FDA) in the United States. GMP compliance is essential to ensure the consistent production of safe and effective products following the public health guidelines.

Laboratoires Activa proudly adheres to these guidelines and holds GMP certification for the manufacturing of all its dietary supplements.

These guidelines define the minimum requirements for the manufacturing processes, facilities, equipment, personnel, and controls necessary to ensure the quality, safety, and efficacy of pharmaceuticals, medical devices, food, and other consumer products.

Key principles of GMP include:

GMP certification is essential for ensuring the quality, safety, and efficacy of pharmaceuticals, medical devices, and other consumer products. This certification is renewed yearly following an inspection from the accredited delivery authorities.
By adhering to GMP guidelines, we demonstrate our commitment to maintaining rigorous standards throughout the production process. This certification provides assurance to worldwide regulatory agencies, healthcare professionals, and consumers that products are manufactured under controlled conditions and meet established quality criteria. Ultimately, GMP certification plays a crucial role in safeguarding public health and maintaining trust in the integrity of the manufacturing industry.

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Exploring the Advantages of
Controlled Release Microgranules in Activa Products

The concept of controlled release microgranules represents a significant advancement in the realm of health supplements, particularly evident in Activa’s product line. These specialised microgranules, an exclusive technology for which Laboratoires Activa holds a patent, offer a distinct advantage over traditional supplement formulations, providing a steady and prolonged release of active ingredients, thereby enhancing therapeutic efficacy and user experience.

Understanding Controlled Release

Controlled release microgranules operate on the principle of gradual and sustained release of active compounds within the body. Unlike conventional supplement formulations, where the release of ingredients occurs rapidly and in a single burst, controlled release microgranules ensure a prolonged and controlled delivery of bioactive components over an extended period.

The Significance of Dissolution Testing

The efficacy of controlled release microgranules is rigorously evaluated through dissolution testing. This analytical procedure serves as a critical quality assessment tool, determining the rate and extent of supplement dissolution in simulated physiological conditions.

In essence, dissolution testing involves mimicking the physiological environment within the body and assessing how efficiently a supplement dissolves. By subjecting Activa’s controlled release microgranules to this testing regimen, we ascertain their ability to sustainably release active ingredients over time compared to conventional formulations.

Beneficial Implications for Consumers

The adoption of controlled release microgranules in Activa products offers tangible benefits to consumers. By ensuring a steady and sustained release of active compounds, these microgranules contribute to prolonged therapeutic effects, fostering improved health outcomes.

Furthermore, the controlled release mechanism minimises the likelihood of abrupt fluctuations in bioavailability, reducing the risk of adverse reactions and enhancing user compliance. This affords consumers a more predictable and comfortable experience, aligning with Activa’s commitment to providing premium-quality health supplements tailored to meet individual needs.

In conclusion, the integration of controlled release microgranules represents a significant stride forward in supplement formulation technology. With its capacity to optimise the delivery of active ingredients, Activa’s products equipped with controlled release microgranules offer a sophisticated solution for individuals seeking enhanced efficacy and convenience in their supplementation regimen.

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The Synergistic Approach
to Immunity & Gut Health:
The Power of Pre and Probiotics

Prebiotics and probiotics complement each other in a synergistic action, fostering a harmonious equilibrium among the diverse bacteria that constitute various microbiotas within the human body. These microbiotas include those found in the mouth, on the skin, in the gut, and the vaginal region.
Prebiotics are indigestible fibers that serve as food for beneficial bacteria in the gut, while probiotics are live microorganisms that provide various health benefits when consumed in adequate amounts. When taken together, prebiotics help nourish and support the growth of probiotics, enhancing their effectiveness in maintaining a healthy balance of the microbiota they compose.
This synergistic combination can help improve the gut or vaginal flora balance, boost immune functions, and promote better digestive health.  

By blending prebiotics with various strains of probiotics, carefully and specifically selected for their benefits, Laboratoires Activa targets precise and optimal results, leveraging their synergistic benefits for effective action.

Activa Symbiotic

12 billion gastro-protected probiotics

• Strengthens the immune system
• Restore the intestinal flora after antibiotics, diarrhea, stress
• Improves bowel motility and uptake of nutrients
• Specific action of B. Infantis strain on Irritable Bowel Syndrome
• Improves Lactose tolerance

Activa Symbiotic Digest

Synergy of plants, prebiotics & probiotics

• Prepares the bolus for a good assimilation in the intestine
• Limits fermentation, nausea, spasms, and slow digestion-related problems
• Promotes a good acid-base balance
• Promotes the microbiota’s development
• Reduces inflammation & regulates intestinal transit

Activa Symbiotic Gyn

10 billion gastro-protected microbriota

• Contributes to vaginal PH balance
• Activates more than 4 times the immunity of the vaginal mucosa
• Prevents bacterial vaginal infections
• Proven antifungal action
• Avoids complications due to antibiotic treatment, proven benefits on vaginal yeast infection

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Nurturing our Future:
The Vital Role of Health Supplements for Children

In today’s fast-paced world, where hectic schedules and evolving dietary choices often dominate our lives, ensuring that children receive the essential nutrients they need can be quite a challenge. In this pursuit, the role of health supplements for children has gained increasing attention and significance.

Health supplements for children can help bridge the nutrient gap and ensure they receive all the vital elements they need for optimal growth. While a balanced diet should always be the primary source of nutrients, supplements can serve as a valuable complement, especially in cases where dietary choices are limited or specific nutrient requirements are not being met.

Activa offers a selection of child-safe health supplements designed to enhance both their development and overall well-being:

Activa is dedicated to ensuring the well-being and growth of the next generation. Our carefully crafted health supplements for children serve as a reliable complement to their daily nutrition. We firmly believe that by providing these essential elements, we contribute to the health, vitality, and brighter future of our young ones.

If you are interested to partner with Activa

Joint support:
The synergy of active ingredients
for a comprehensive approach

Chondroitin and glucosamine are 2 compounds often used together in health supplements for joint support because they have complementary properties and benefits on joint health.

Glucosamine is naturally made by the body from amino acids, and is found in cartilage, and plays a key role in maintaining its integrity, structure and function in the joints.
Metabolic deficiency or ageing, may compromise the body’s cartilage production that becomes insufficient: degeneration sets in and leads the way to osteoarthritis. Glucosamine helps to stimulate the production of new cartilage and reduces the degradation of the existing one.

Several studies have shown that glucosamine hydrochloride reduces pain, improves mobility, and speeds healing in people with cartilage injuries[1,2]. It also helps to act on pain due to rheumatoid arthritis[3]. By increasing the lubrication of synovial fluids in the joints it helps slow cartilage degradation, unlike conventional anti-inflammatories which, in the long term, accelerate joint degeneration[4].

Chondroitin is naturally produced by the body and is an essential constituent of cartilage that provides hydration, elasticity, flexibility[5], and shock-absorbing properties to connective tissues. Several meta-analyses and syntheses concluded its effectiveness in relieving symptoms of mild to moderate osteoarthritis[6].

As a chondroprotective:
– It promotes the synthesis of cartilage cells and hyaluronic acid, allowing lubrication,
– It protects against enzymatic reactions and free radicals
– It could inhibit osteoclasts, responsible for bone loss.

Backed up by medical studies:
Studies have suggested that combining glucosamine and chondroitin may be more effective than taking either one alone. In 2005, a study published in the New England Journal of Medicine found that a combination of chondroitin and glucosamine was more effective at reducing pain and improving function in people with osteoarthritis than either supplement alone.

Two American studies conducted double-blind and controlled by placebo, indicating that the combined intake of glucosamine hydrochloride and chondroitin sulphate has been shown to be effective in relieving the symptoms of osteoarthritis of the knee[7,8].
The GAIT (Glucosamine/Chondroitin Arthritis Intervention Trial) specific study, conducted in 2010 for 24 weeks, obtained results in the same direction, on subjects suffering from moderate to severe pain[9].

Together, chondroitin and glucosamine work synergistically for joint support by helping to slow or stop the degeneration of joint tissues[10], and stimulate the synthesis of new cartilage, while regulating the enzymes responsible for their destruction.

Glucosamine and Chondroitinhave a complementary action
to ‘TSE’ * on the protection of cartilage

Additionally, it has been found that combining glucosamine and chondroitin with other ingredients in a health supplement can further support joint health, help reduce inflammation and provide additional support for joint tissue.

Associating Turmeric Super Extract ‘TSE” (Curcumin extracted with a specific extraction technique to make it highly bioavailable to the body), with chondroitin and glucosamine can provide several benefits for joint health by potentiating the protective action of the cartilage provided by the TSE.

TSE has strong anti-inflammatory (as effective as NSAID), natural chondroprotective and antioxidant properties.

While each ingredient has its own unique properties, they work synergistically to provide joint support, including reducing inflammation, supporting cartilage health, improving joint mobility, and providing antioxidant protection. This comprehensive and synergistic approach results in greater overall benefits for joint health compared to using each ingredient individually.
Activa Joint Well-Being is the result of our research on the body’s ability to self-regulate in the face of dysfunction.

In conclusion, Activa Well Being Joint, is the synergy of selected natural compounds to support a comprehensive and global approach to joint health.
Its purpose is to promote the protection and regeneration of cartilage as well as the reduction of inflammation and pain, and allows increased mobility. The formulation of Activa Well Being Joint is highly bioavailable and biocompatible.
Its galenic form, the extended release microgranule allows a reduced intake of 1 capsule to feel relieved for 8 hours.

If you are interested in this products

Sources:
[1] Braham R, Dawson B, Goodman C. The effect of glucosamine supplementation on people experiencing regular knee pain. Br J Sports Med. 
[2] Glucosamine administration in athletes: effects on recovery of acute knee injury. Ostojic SM, Arsic M, et al. Res Sports Med. 2007 Apr-Jun;15(2):113-24.13.
[3] Nakamura H, Masuko K, et al. Effects of glucosamine administration on patients with rheumatoid arthritis. Rheumatol Int. 2007 Jan;27(3):213-8
[4] Towheed TE, Maxwell L, et al. Glucosamine therapy for treating osteoarthritis. Cochrane Database Syst Rev. 2005 Apr 18;(2):CD002946.
[5] J. Theodosakis. The Arthritis Cure
[6] Monfort J, Martel-Pelletier J, Pelletier JP. Chondroitin sulphate for symptomatic osteoarthritis: critical appraisal of meta-analyses. Curr Med Res Opin. 2008 May;24(5):1303-8.
[7] Das, A. and Hammad, T.A. Efficacy of a combination of FCHG49 glucosamine hydrochlo- ride, TRH122® low molecular weight sodium chondroitin sulphate and manganese ascorbate in the management of knee osteoarthritis. Osteoarthritis Cartilage. 2000 Sep;8(5):343-50. 
[8] Leffler CT, Philippi AF, et al. Glucosamine, chondroitin, and manganese ascorbate for degenerative joint disease of the knee or low back: a randomized, double-blind, placebo-controlled pilot study. Mil Med. 1999 Feb;164(2):85-91
[9] legg DO, Reda DJ, et al. Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis, N Engl J Med, 2006 Feb 23;354(8):795-808. 
[10] Clegg DO et coll. Glucosamine, chondroitin sulfate, and the two in combination for pain- ful knee osteoarthritis, N Engl J Med, 354(8) : 795-808

Laboratoires Activa at Infarma Spain

During this 3 days show, our Spanish team presented our natural supplements that are already highly recommended in pharmacies throughout Spain.

True to our values, we support our staff and partners in promoting supplements, by offering personalised trainings, sales and marketing tools, as well as very attractive pricing conditions.

Activa Omega 3 Supplements
– The innovation that makes the difference –
High bioavailability, purity and reduced dosage

Omega-3 fatty acids are essential nutrients that are important for overall health and wellness. They offer great health benefits, including reducing inflammation, improving heart health, and supporting brain function. There are two main forms of omega-3 fatty acids that are commonly found in fish oil based supplements: Ethyl Ester (EE) and Triglyceride (TG) forms.
The primary difference between omega-3 EE and TG forms lies in The chemical structure of their nucleus.

In the EE form, the nucleus is chemically modified to create an ethyl ester, which allows to enrich it with EPA/DHA in the required proportions and purify them. Unfortunately the downside is that they have a low availability and oxidise fasts.

In contrast, the TG form is the natural form of omega 3, this is how it is found in fish and this is how we store and use it in our bodies. Its bioavailability is excellent. However, natural fish oils are not very concentrated in EPA/DHA and they contain impurities.
As a consequence; to have the right dose of fatty acids, it is necessary to take a large dose of oil (and its impurities), which can affect digestion and intestinal transit.

A solution is to transform these TG oils into EE, this process is called transesterification. To put it simply, EPA/DHA is separated from its glycerol support, purified and recombined with an alcohol (ethanol). Through this chemical manipulation, we obtain purified fatty acids that can be concentrated in EPA/ DHA as desired.

However, an important downside is that EE oil oxidises more quickly. Moreover, as this is a new form that does not exist in nature, our body has, unfortunately, high difficulty assimilating it as it doesn’t have the enzymes necessary to separate EPA and DHA from its ethanol support. Some studies show that the absorption of a TG vs EE oil ranges from 71% to 400%…

Another option, which is costly because it involves a long and complicated process, is to take the EE oil and separate it from its ethanol support, and recombine it in TG form by adding glycerol.
As a result, we have the best of both worlds: a purified oil with a high concentration of EPA DHA .
Moreover, this oil has also a better resistance to oxidation thanks to a specific airless encapsulating method.
It means that thanks to this specific transformation process, this oil is highly concentrated in EPA and DHA, and because it has a low oxidation, you can ingest small doses (in the form of small soft gel capsules (while most products are hard and large capsules), achieve a high bioavailability and enjoy its health benefits.

How do you know if your oil is in TG or EE oil?

If TG is indicated on the packaging, it means that it is in the triglyceride form, however if it is not indicated the oil is an EE form.

Laboratoires Activa’s Omega3 supplements combine expertise and technology to deliver a high quality and efficacy product. Activa Well Being Memory and Activa Well Being Cardio are the result of a long and specific research on the synergistic action of 2 specific EPAX® TG oils, produced using the innovative EE to TG transformation process described above, and using an airless encapsulation method from oil extraction to soft capsule.

It is the synergy of the 2 oils used which allows to obtain a balanced blend of omega 3 supplement highly bioavailable in EPA and DHA and purified.

If you are interested in these products

Preventing the side effect of antibiotics therapy

Antibiotics are drugs used to fight infections, however, all infections are not treated with antibiotics: antibiotics only work against bacterial infections and are not effective against viral infections such as the common cold or the flu.

When you take antibiotics, they not only kill the harmful bacteria that are causing the infection, but they can also kill some of the beneficial bacteria in your gut.

Taking a probiotic supplement during and after a course of antibiotics can help to restore the balance of bacteria in your gut. This can also help to reduce the risk of antibiotic-associated side effects like diarrhea, vaginal yeast infections, and other digestive problems.

In addition, some studies have suggested that taking probiotics during antibiotic therapy may help to reduce the risk of antibiotic-resistant infections by preventing the overgrowth of harmful bacteria that can become resistant to antibiotics.

It’s important to note, however, that not all probiotics are the same, and different strains of bacteria may have different effects. Laboratoires Activa has developed a range of 3 pre and probiotics blend targeting specific actions and effects in the body.

Diarrhoea

About 1 in 5 person[1] who take antibiotics develop antibiotic-associated diarrhea. Most often, the diarrhea is mild, requires no treatment, and clears up within a few days after you stop taking the antibiotic. However, it is a sign that the balance of the gut microbiome has been affected and taking antibiotic therapy is highly recommended.

Activa Well Being Symbiotic

Support the intestinal flora during and after antibiotic therapy

2 caps in the morning on an empty stomach during antibiotic therapy
1 cap in the morning on an empty stomach 1 month after antibiotic therapy

Discover Activa Well Being Symbiotic ➤

Vaginal yeast infections

Yeast infections are common in women who take antibiotics[2]. A lot of antibiotics, which kill some of the bad bacteria, also kill healthy bacteria in your vagina, leading to overgrowth of yeast. Protecting your vaginal flora during and after antibiotic therapy (especially when taking cyclines that promote vaginal yeast infections) will help you avoid having a vaginal yeast infections.

Activa Symbiotic Gyn

Protect vaginal flora during and after antibiotic therapy

2 caps before breakfast on an empty stomach
15 days to 1 month of course

Discover Activa Well Being Symbiotic Gyn ➤

Digestive discomfort

Taking antibiotics can really change the amount and type of bacteria in the gut[3] but also the whole digestive system. These changes in the gut microflora can lead to antibiotic-associated nausea, vomiting and other gastrointestinal side effects.

Activa Symbiotic Digest

Maintain the whole digestive flora during and after antibiotic therapy

1 to 2 caps a day in the morning on an empty stomach during antibiotic therapy
15 days to 1 month of course

Discover Activa Well Being Symbiotic Digest ➤

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Sources:
[1]https://www.mayoclinic.org/diseases-conditions/antibiotic-associated-diarrhea/symptoms-causes/syc-20352231#:~:text=About%201%20in%205%20people,you%20stop%20taking%20the%20antibiotic.
[2]https://www.mayoclinic.org/diseases-conditions/yeast-infection/symptoms-causes/syc-20378999#:~:text=Yeast%20infections%20are%20common%20in,leading%20to%20overgrowth%20of%20yeast.[3]https://www.henryford.com/blog/2020/06/antibiotics-and-probiotics-how-medications-affect-your-gut#:~:text=A%3A%20Taking%20antibiotics%20can%20dramatically,recommend%20taking%20antibiotics%20with%20food.

Activa for Women’s Lives

A woman’s life is rhythmed by her menstrual cycle from puberty to menopause.

Its reproductive system repeats a regular pattern dependent on her hormones to prepare her for a possible pregnancy.

Many inconveniences, or even illnesses, can be related to the menstrual cycle, pregnancy or menopause, and affect a woman’s life:

• Menstruation disorders:
  premenstrual syndrome, painful menstruations
• Endometriosis
• Pregnancy disorders: morning sickness and other digestive issues, constipation, circulatory problems, hemorrhoids, hair loss, lower back pain, skin problems, neuro-psychic disorders…
• Postpartum disorder: “baby blues”
• Symptoms of perimenopause, then menopause:
  hot flashes, fatigue, irritability, sleep disturbances, loss of libido, vaginal dryness…

Today, every woman can live her feminine expression; her cycle, as comfortably as possible, regardless of age…using Activa natural solutions for women’s health.

The Feminine Sphere

Women by Activa

Contact us to get more information
on Activa’s Women’s products