Hypertension : The Natural Solution

Arterial hypertension(or high blood pressure) affects around 20% of the French adult population, and it is also the most frequent cause of cardiovascular problems. The risk of suffering from it increases with age. A person is considered to have high blood pressure when diastolic pressure is over nine and systolic pressure is over 14 – being respectively the lower and upper numbers recorded when measuring blood pressure.

High blood pressure is considered as a “silent” or “insidious” disease, as many people do not realize that they have it until symptoms arise. Besides, very few people regularly get their blood pressure checked. Yet, that illness causes major cardiovascular complications and leads to 62% of strokes as per the WHO. The excessive mechanical pressure upon the arteries causes anomalies and fosters rigid artery walls. It therefore increases the risk of atheroma appearing or worsening.

The most frequently affected arteries are the carotid (brain), coronary (heart), kidneys and lower limbs. Thus, some risks are heightened, such as the following consequences: strokes, ischemic heart disease (angina and heart attacks), peripheral arterial disease (narrowing of the arteries supplying blood to the legs) and chronic kidney failure. The fragilized arteries may also require dialysis in the long term. Moreover, the high blood pressure indirectly increases the heart’s activity – because it maintains a constant blood flow – and then leads to left ventricular hypertrophy and gradual loss of its contractile activity (possible outcome is heart failure). In that respect, high blood pressure is mainly critical because of its long-term consequences on various organs. Conventional medicine offers a range of “solutions”: diuretics, beta-blockers (to reduce the heart beat) and calcium channel blockers (to diminish vascular resistance) etc. However, these treatments are symptomatic and go along with side effects.

Naturally regulating blood flow and blood pressure helps limiting the risks of heart diseases, while effectively protecting the body.

Which plants are most effective?

Red vine: blood flow regulation

– Resveratrol (grape skins) is a powerful antioxidant which has shown promising anti-ageing effects on some primitive animal species. Overall, it protects and s timulates the circulatory system.

– Anthocyanins (red vine leaves) reduce capillary permeability and increase their resistance, thus preventing the venous circulation to stagnate. In grapes, this action is potentialized by the presence of tannins, astringents and vasoconstrictors (the OPC): they facilitate venous return. Refer to the properties of grape seeds for further information.

Therefore, consuming red vine extracts helps protecting the venous system by maintaining the elastic fibers, re-establishes circulation, prevents and reabsorbs oedema.

Grape seeds : better circulation

Grape seeds are particularly rich in OPC antioxidant, which are 20 times as efficient as Vitamin C and 50 times as efficient as Vitamin E. OPC have a perennial impact on free radicals, the latter being responsible for various disorders within the circulatory system. Indeed, free radicals destroy cellular membrane, damage collagen and lead to the hardening of arteries (increased risk of high blood pressure). As opposed to those disorders, OPC improve blood vessel elasticity, prevent blood platelets from sticking together, hence reducing the risk of blood clots and aphasia. Moreover, those complexes also help diminishing the amount of cholesterol deposed on blood vessel walls. Grape seeds finally boost exceptional anti-inflammatory and anti-oedema properties.

Numerous clinical studies have been conducted in France to demonstrate how grape seeds can be used to treat capillary fragility and varicose veins. In a double-blind study, 71 patients with venous insufficiency were divided in two groups. Each group was given a daily dose of 300mg of either grape seed anthocyanidins or a placebo. 75% of the former showed significant reduction in functional symptoms, compared to 41% of the latter. Tests show that administering anthocyanidins enhances venous tone in patients with extensive varicose veins. Another clinical trial featured two groups of geriatric patients suffering from low capillary resistance. Each group was treated with 100-150mg of either anthocyanidins or placebo. 50% of the former showed improved capillary resistance after two weeks.

Blueberry to strengthen the capillaries

Blueberries are rich in Vitamin C and contain iron, magnesium, potassium and phosphorous. They are also composed of a record-breaking quantity of flavonoids with anti-cancerous, antioxidant and fluidizing properties. Apart from other phenolic components, blueberries contain a high concentration of anthocyanins, which positive effects have been described above.

Numerous clinical and epidemiological studies have sorted out the causality that exists in the relationship between the consumption of blueberries (flavonoids) and the reduction of cardiovascular and degenerative diseases. The phenolic compounds contained in blueberries should also reduce blood lipid oxidation, consequence of oxidative stress and inflammation of the vascular system. As a matter of fact, a placebo-controlled and double-blind study of 60 patients with chronic venous insufficiency showed a substantially improved condition after 30 days of treatment with blueberry extracts.

To conclude, we have seen that blueberries strengthen the capillaries by protecting them from oxidation, improve the contractile function of blood vessels and stimulate the regeneration of the rods in the retina. For the record, RAF pilots used to eat large quantities of blueberries before nocturnal flights during WW2 to improve their eyesight.

Meadowsweet to improve blood flow

Meadowsweet has been known for centuries and among other components contains salicylic derivatives (including salicyl aldehyde, methyl salicylate etc), which are forerunners of acetylsalicylic acid, universally known as aspirin. Just like aspirin, meadowsweet has anti-inflammatory and analgesic properties, yet it also has a major advantage over aspirin, as it is extremely safe. Unlike aspirin (synthetic), which causes ulcers and bleeding in the stomach when used for extended periods of time, meadowsweet combats gastric acid. It also contains flavonoids, tannins and a number of trace elements, such as iron, sulphur and calcium.

Meadowsweet has the following recognized properties:

– Anti-inflammatory and anti-rheumatic and is recommended for chronic pain, migraines, throat infections, laryngitis etc.
– Thins the blood (Vitamin K).
– Fever reduction (salicylic derivatives).
– Gastroesophageal anti-acidic properties.
– Diuretic and astringent (flavonoids and mineral salts): it powerfully clears uric acid from the body.
– Intestinal antispasmodic and urinary pain sedative.
– Diarrhoea prevention.

It is also recommended to treat cellulite, arteriosclerosis and all diseases related to the body being overloaded with waste.

Olive leaves to naturally lower blood pressure

Moreover, olive leaf extract is proven to be effective, making it a safe preventive and therapeutic treatment for high blood pressure. It improves circulation by relaxing and dilating the arteries and also aids diuresis, reduces oedema (fluid retention) and blood urea nitrogen levels.

Why? Because it contains components such as :

– Oleuropein, a significant oxidation inhibitor.
– Oleuropeoside lowers blood pressure and is effective against the effects of high blood pressure, such as headaches, dizziness and buzzing in the ears. It also has diuretic, hypoglycaemic and anti-spasmodic properties and vasodilatory and anti-arrhythmic action.,
– Flavonoids – these are antioxidants which help to neutralise free radicals and play an important part in protecting artery walls.

According to a University of Milan study, olive leaves help prevent arteriosclerosis and coronary diseases. The properties of olive leaves enable them to reduce ‘bad’ cholesterol (LDL) and increase ‘good’ cholesterol (HDL), which in particular makes them an invaluable complement when treating non-insulin dependent diabetes.

Blackcurrant – anti-oxidant and purifying properties

Blackcurrants are also vasoprotective and venotonic. They boost capillary resistance and permeability, thus improving microcirculation. In this respect, they can be used to prevent and treat symptoms of capillary fragility (rosacea and broken blood vessels on the legs). Blackcurrant in particular counters blood vessel wall aging.

We also know that blackcurrant seeds are rich in essential fatty acids from the Omega 3 family (such as alpha-linoleic acid and stearidonic acid) and the Omega 6 family (gamma-linolenic acid, for example). These fatty acids are thought to have blood pressure lowering and anti-inflammatory properties.

They are also unique because the body is able to effectively assimilate the elements contained in the seeds. They are circulated in the blood and then excreted in urine and are effective along the length of the tract.

A blend of six plants acts effectively and comprehensively

Each of the aforementioned plants contains components with their own unique properties and which seem similar. However, it is important to stress that these plants need to be “combined” to achieve a targeted and comprehensive effect.

Only a complex of active ingredients enables the body to effectively regulate blood flow and blood pressure by acting on several “fronts”. Please be aware: consuming complexes of plant extracts can be dangerous and in light of the differing compositions of natural products on the market, it is vital to check the origin, dosage and concentration of the main active ingredients in products. Moreover, while many products are available containing dry extracts taken from one or all six of the plants I have mentioned, few offer carefully-developed blends to ensure maximum effectiveness in order to have a comprehensive and synergetic impact. Indeed, active ingredient synergy is an additional piece of information for the body, telling it where and when the active ingredients will act, without ever interacting!

– It contains a carefully-developed blend of dry extracts of red vine leaf, grape seed, blueberry, meadowsweet, olive leaf and blackcurrant, known to reduce high blood pressure and aid blood flow
– The complex also contains bearberry, galega and grapefruit, known for their hypoglycaemic properties
– The complex contains 100% natural active ingredients, with a “smart” and sequential formula designed to ensure that the ingredients act effectively and in synergy
– It is fully bio-available and bio-compatible
– It acts on the circulatory system as a whole and effectively regulates blood pressure
– The complex contains 100% natural active ingredients, with a “smart” and sequential formula designed to ensure that the ingredients act effectively and in synergy
– It is fully bio-available and bio-compatible
– It acts on the circulatory system as a whole and effectively regulates blood pressure
– The complex aids microcirculation thus acting on the whole vein system
– The complex ensures a healthy blood balance by acting on sugars and cholesterol
– It is compatible with medical high blood pressure treatments
– As the result of the latest drug innovations, it comes in the form of “controlled-release” micro-granules in order to ensure that the active ingredients are released in the body in an extended and targeted fashion so that optimum results are achieved.

The result of the latest pharmaceutical innovations, it is presented in a special microgranular form

The microgranules have a biocompatible neutral core (patented), and a semi-permeable membrane that protects and releases 96% of the active ingredients (no contamination by dust and moisture, no risk of sticky clumping in a wet environment).

The microgranules also provide greater protection in the stomach, thus eliminating any side effects

They ensure improved compliance due to the reduced dosage, and greater comfort due to masking the taste and odour of plant extracts

Sources:
[1] Source INSERM – www.inserm.fr/thematiques/circulation-metabolisme-nutrition/dossiers-d-information/hypertension-arterielle
[2] EMA study:
[3] Henriet JP. Exemplary study for a phlebotropic substance, the EIVE Study [translated from French]. Fairfield, Conn: Primary Source; not dated. Study mentioned and summarised in: Natural Standard (Ed). Herbs & Supplements – Grape seed (Vitis vinifera, Vitis coignetiae), Nature Medicine Quality Standard. http://www.naturalstandard.com/
[4] Delacroix P. Double-blind study of Endotelon W in chronic venous insufficiency [translated from French]. La Revue de Médecine. Aug/Sept.1981;no.27-28:1793- 1802. Study mentioned and summarised in: Natural Standard (Ed). Foods, Herbs & Supplements – Grape seed (Vitis vinifera, Vitis coignetiae), Nature Medicine Quality Standard. www.naturalstandard.com
[5] Pizzorno JE Jr, Murray Michael T (Ed). Textbook of Natural Medicine, Churchill Livingstone, US, 1999. p. 994.
[6] Royer R.J., Schmidt C.L., “Evaluation of venotropic drugs by venous gap plethysmography. A study of procyanidolic oligomers “, Sem. Hop., 1981, 57:2009-2013.
[7] Dartenuc J.Y., Marache P., Choussat H., “Capillary resistance in geriatry. A study of a microangioprotector Endotelon”, Bor. Med., 1980, 13:903-907.
[8] Neto CC. Cranberry and blueberry: evidence for protective effects against cancer and vascular diseases. Mol Nutr Food Res. 2007 Jun; 51(6):652-64.
[9] Gatta L., “Experimental single-blind study: 60 pts with venous insufficiency received bilberry extract equivalent to 173 mg anthocyanins daily of placebo for 30 days”, Fitoterapia, 1988, 115:109-116.
[10] Kay CD, Holub BJ. The effect of wild blueberry (Vaccinium angustifolium) consumption on postprandial serum antioxidant status in human subjects.
[11]Pizzorno JE Jr, Murray Michael T (Ed). Textbook of Natural Medicine, Churchill Livingstone, US, 1999. p. 994.
[12] Susalit E, Agus, N Olive (Olea europaea) leaf extract effective in patients with stage-1 hypertension: Comparison with Captopril., Effendi I et al. Phytomedicine. 2010 Oct 29.
[13] Syed Haris Omar, Oleuropein in Olive and its Pharmacological Effects.
[14] Research on blackcurrants: “Antioxidant Activity of Black Currant Anthocyanin Aglycons and Their Glycosides Measured by Chemiluminescence in a Neutral pH Region and in Human Plasma”. Matsumoto, H., Y. Nakamura, et al. (2002). J. Agric. Food Chem. 50(18): 5034-5037
[15] Thesis on “Le Cassis (ribes nigrum L.) : études botanique, chimique et effets thérapeutiques”, Stéphanie GERBAKA, Grenoble 2013

Spirulina the “superfood”

Spirulina is a microscopic spiral-shaped alga, has existed for 3.5 billion years and yet has not aged a day. It belongs to the cyanobacteria group, which turns carbon dioxide into organic matter by using photon energy. The oxygen is then released through a complex process.
Spirulina is still involved in creating organic substances boosting the evolution of beings thanks to its phycocyanin.

Aside from its nutritional benefits, its therapeutic properties are real. Indeed, Health Organisation of the United Nations has recommended the use of Spirulina since 1996. It promotes its action against malnutrition and lack of micronutrients. As a matter of fact, 70 countries are currently using it to fight malnutrition. The reasons are multiple:

– It provides more than 100 nutrients, including: amino acids, minerals, rhamnose sugar (a complex sugar from plants), trace elements (calcium, phosphorus, magnesium, iron, zinc, copper, manganese, chromium, sodium, potassium and selenium), enzymes (superoxide dismutase, etc.) and vitamins A, D, E, B1, B2, B3, B6, B7, B8, B12 and K.

– It is an extraordinary source of various carotenoids (mainly beta-carotene, but also cryptoxanthin, lutein, zeaxanthin, etc.). Spirulina contains 30 times as much beta-carotene (antioxidant) as carrots do.

– 55% to 70% proteins oof the proteins it contains are excellent quality molecules, rich in essential amino acids including leucine (key amino acid in the synthesis of muscular proteins). Its proteins are also the easiest to digest, thus the most suitable for individual whose intestines have trouble absorbing nutrients.. Clinical studies have shown that Spirulina helps rebuild a healthy intestinal flora by boosting the proliferation of lactobacilli.

What is more, 40% of the fatty acids within Spirulina are gamma-linolenic acids, which is a precursor in the mediation of inflammatory and immune reactions. That makes it one of the most prized sources of scarce gamma-linolenic acids. Furthermore, its fatty acids contain high concentration of omega-3 and 6, which are known for preventing the build-up of cholesterol.
An excellent source of iron and provides fully bioavailable magnesium.

Spirulina, is rich in phycocyanin, a group of proteins and pigments involved in Spirulina photosynthesis, which results in its blue-green color. Multiple studies have shown the therapeutic value of this pigment: indeed, it enhances cell oxygenation and promotes red cells, white cells and platelets productions. A milestone experiment on its therapeutic effects undeniably was the one performed on two hundred and seventy Chernobyl children with radiation-damaged bone marrow: when given Spirulina, they became healthy within a six weeks-period. Indeed, the production of red and white blood cells re-activated despite an irremediably damaged immune system.

The phycocyanin of Spirulina is also a powerful detoxifying agent for the liver and kidneys, promotes the production of bile salts and the fecal elimination of cholesterol.

Spirulina is therefore prescribed as an agent against deficiencies and malnutrition, as well as an immunity booster. Finally, it also protects the liver, aids in weight loss and intervenes in the prevention of numerous serious illnesses, such as: cancer, fibromyalgia, hay fever, herpes infection, high cholesterol, hives and HIV infection.

Spirulina, the healthy friend of dieters!
Besides all its therapeutic applications, Spirulina is very helpful to those eager to lose weight … without losing tone and feeling down. It allows a reduced calorie intake during mealtime without hunger, irritability, drowsiness and lack of drive. In the meantime, the muscle mass remains intact.

It provides the body with all the nutrients needed to ensure its vitality and proper function (previous paragraph), and is yet very low in calories. It especially counters the shortfalls in iron and vitamin A resulting from restricted diets (refer to the ANSES’ report, the French national agency for nutritional, environmental workplace safety).

Moreover, Spirulina cellular membranes are mostly made of polysaccharides, which are highly sensitive to digestive juices. Its constituents are easily absorbed with minimal intervention from insulin, thus limiting sugar levels and sugar accumulation – ending up as fat. Meanwhile, Spirulina delivers energy almost immediately since it is rich in quick-release sugars; therefore, it neither strains the pancreas nor triggers low levels of blood sugar.

Spirulina is also source of the amino acid phenylalanine, a precursor of the hormone cholecystokinin (CCK), which is produced by the brain to signal satiety. Therefore, phenylalanine increases the concentration of CCK in the system, thus suppressing the feeling of hunger. It also favors positive mood swings as agent of the synthesis of noradrenaline and dopamine, two neurotransmitters with antidepressant effects.

Like Spirulina, cress contains very few calories (only 17 kcal per 100 grams) while remaining very rich in nutrients! These two plants combined potentialize each other’s properties, provide nourishment, and make the body burn calories in the process.

How to best eat them to ensure their efficiency?
Supplements based on Spirulina or cress separately are available in the shops, but it is much harder to find a well-designed blend of these two plants. Again, consuming complexes of plant extracts can potentially be dangerous; because of the great variation in the composition of natural products sold on the market, it is critical to check the origin, quantity and concentration of the active ingredients that they contain.

As a matter of fact, Well Being Spirulina is 100% natural, bioavailable, biocompatible, without desirable side effects. This active complex is designed as a specifically blend of Spirulina and cress dry extracts, which proportions and quality are an excellent support to weight loss and dieting.

The microgranules have a biocompatible neutral core (patented), and a semi-permeable membrane that protects and releases 96% of the active ingredients (no contamination by dust and moisture, no risk of sticky clumping in a wet environment).

The microgranules also provide greater protection in the stomach, thus eliminating any side effects

They ensure improved compliance due to the reduced dosage, and greater comfort due to masking the taste and odour of plant extracts.

Blinkova et al, 2001 – Falquet J, Hurni JP (2006) Spiruline, Aspects Nutritionnels [Spirulina, Nutritional Aspects]. Antenna Technologies, Geneva. – Ciferri O (1983) Spirulina, the Edible Microorganism. Microbiological Reviews 47: 551-578. – Cohen Z, Reungjitchachawali M, Siangdung W, Tanticharoen M (1993) Production and partial purification of γ-linolenic acid and some pigments from Spirulina platensis. Journal of Applied Phycology 5: 109-115. – Planes P, Rouanet J-M, Laurent C, Baccou J-C, Besancon P, Caporiccio B (2002), Magnesium bioavailability from magnesium-fortified spirulina in cultured human intestinal Caco-2 cells. Food Chemistry 77: 213-218. – Campanella L, Crescentini G, Avino P (1999) Chemical composition and nutritional evaluation of some natural and commercial food products based on Spirulina. Analusis 27: 533-540. – Thus, this substance facilitates the differentiation of stem cells in bone marrow by stimulating the secretion of the hormone erythropoietin or EPO. – Chamarro et al. 2002 http://iimsam.org/en/iimsam-spirulina-resource-centre/ – https://www.anses.fr/fr/system/files/NUT2009sa0099.pdf – Brennan P, Hsu CC, et al. Effect of cruciferous vegetables on lung cancer in patients stratified by genetic status: a mendelian randomisation approach. Lancet 2005 October 29;366(9496):1558-60. – Pan SY, Ugnat AM, et al. A case-control study of diet and the risk of ovarian cancer. Cancer Epidemiol Biomarkers Prev 2004 September;13(9):1521-7.

Relief and Prevention of Gastritis

Who has never suffered from gastritis? In France, gastritis affects 30% of French adults and 50% of French people over 50! The individuals affected use standard remedies, hence subjected to many relapses.

Gastritis is a chronic inflammation of the gastric mucosa – the membrane lining the stomach. It might be an isolated incident – caused by a bacterium or a virus – but it is mostly chronicle. It creates intense heartburn and digestive disorders.

Gastritis may result either from a frequent autoimmune reaction – induced by Helicobacter pylori (observed in 80% of cases) or from external and chemical aggressions (e.g. consumption of alcohol, tobacco or some medicines). The trigger is not so easily identified, though it appears that stress might often be involved – especially chronic, as a direct or indirect cause.

Cures exist either to help reducing or neutralizing the heartburn, or to support the healing of ulcers. Indeed, antibiotics are commonly used when a Helicobacter pylori infection is diagnosed. Overall, it is recommended to refrain from smoking, drinking alcohol or taking medications which are likely to cause heartburn (as a side effect). Warnings are also valid regarding strict diets.

Alternatives exist for the natural and permanent relief and prevention of gastritis, namely …

Fenugreek : a potent anti-ulcer agent

Fenugreek, (Trigonella foenum graecum) is one of the oldest medicinal plants on Earth. This Mediterranean leguminous plant is highly rich in oligo elements and amino acids. Indeed, it contains phosphorus, iron, Sulphur, nicotinic acid, alkaloids, flavonoids, carbohydrates, vitamins A, B1, and C, magnesium, calcium, lecithin, proteins (30%) and steroidal saponins. Overall, those elements contribute to the synthesis of cholesterol and fibers.

Fenugreek stimulates the appetite and is known for its anti-ulcer properties. Several studies have been conducted to investigate its impact on gastric ulcers ^(1,2) by comparison with other drugs – such as omeprazole. They showed that Fenugreek seeds exert a potent cryoprotective impact thanks to:

– Its mucilage and galactomannans, which protect the gastric mucosa and functions, and both the small intestine and colon. Indeed, they help soothing gastrointestinal inflammation by forming an efficient protection of the intestinal environment,
– Its quick and powerful inhibitory action upon the secretion of hydrochloric acid (by parietal cells of the stomach),
– Its significant role in the reduction in lipid peroxidation – caused by ethanol – and red cell deterioration by sustaining the activity of antioxidant enzymes (catalase and SOD). Lipid peroxidation plays a major role in the inflammation of the gastric mucosa and the formation of lesions. The mentioned study also highlighted that Fenugreek seeds are more effective than omeprazole as a preventive treatment.

The above elements lead to the conclusion that Fenugreek holds a real anti-ulcer potential.

Besides, Fenugreek acts as a tonic when fatigue kicks in, as a pancreatic stimulant and as an anti-inflammatory. Fenugreek leaves are bitter, hence fortifying the liver and stimulating the production of bile. The latter is more easily expulsed from the gallbladder, thus stimulating the biliary excretion of cholesterol while simultaneously reducing both levels of triglycerides and LDL cholesterol in the blood. Finally, further studies have found out that Fenugreek could also have a preventive effect on the onset of colon, breast and gallbladder cancers.

Fenugreek Hydroxy Isoleucine

Researchers discovered that Fenugreek seeds also contain an unconventional amino acid with highly interesting insulin-stimulant properties ⁽³⁾ – the 4-hydroxyisoleucine. This molecule does not exist either in human or animal cells, and stimulates the secretion of insulin by targeting pancreatic cells. The main interest of hydroxy isoleucine is that it truly differs from sulfonylureas, which are currently used in the treatment of diabetes: indeed, the latter causes hypoglycemic side effects⁽⁴⁾, as opposed to 4-hydroxyisoleucine. Nonetheless, it is necessary to specify that only 100% natural Fenugreek extracts provide the efficient quantity of 20% hydroxyisoleucine.</>

Melissa : Antispasmodic and Choleretic

Different studies ^(5,6) have drawn attention on the active substances of lemon balm, such as:
– terpene aldehydes, which have antiviral, calming and sedative properties. They have also antihypertensive, stomachic, antibacterial and anti-inflammatory qualities,
– terpene alcohols, which exert a neurotonic, liver stimulating and immunomodulating effects. They influence emotional and mental states,
– carophyllene contained in sesquiterpenes, which hold has anti-inflammatory, anti-colic and antispasmodic properties.

Those researches have enabled the WHO and other health agencies (EMA, ESCOP) to validate the positive effects of lemon balm. They have especially brought to light its impact on digestive disorders, such as pain, gastrointestinal spasms and bloating. Furthermore, it helps easing digestion, and boosts the prevention of nausea and vomiting by nurturing bile secretion. Its soothing action also fights against nervous tension and irritability, and facilitates the onset of sleep.

Dandelion : Detoxifiant and Stimulant for the liver

Sage : Anti-bloating and digestion stimulant

Sage has been known for ages as an excellent source of vitamin K and iron. It is mainly recommended for its relaxing and antispasmodic action on both the stomach and the intestinal muscles. It is also known for its ability to increase the secretion of bile ⁽⁹⁾.
Thus, Sage helps easing stomach cramps and protects the gastrointestinal track (heartburn). It is particularly effective against bloating and intestinal gas.
Studies on rodents have shown that Sage significantly stimulates an antioxidant enzyme produced by the liver⁽¹⁰⁾. Besides, it contains two phenolic compounds with proven antioxidant properties – Rosmarinus acid and luteolin.

Four plants combined towards an effective and sustainable effect !

The combination of Fenugreek, Lemon balm, Dandelion and Sage soothes inflammation induced by gastritis, reduces stomach and intestinal spasms, and stimulates the liver. It also helps reaching an internal equilibrium that prevents relapses, especially in case of chronic gastritis.

However, preparing this combination yourself is ill-advised: indeed, while numerous product complexes using dry extracts of these four plants are available on the market, very few are designed with a synergistic action. The synergy formed by the active elements is additional information for the body, since it indicates a time and location for the substances to act – leading to emerging properties without interacting whatsoever ! Furthermore, it is crucial to pay attention to the biological qualities, the origin and proportions of the extracts.

– It consists of Fenugreek containing 20% hydroxyisoleucine.
Combined with a carefully studied combination of sage, dandelion and lemon balm,
– It relieves pain and cramps resulting from gastritis,
– It helps restoring its balance to the gastric mucosa and intestines, and prevents chronic gastritis,
– It stimulates digestion and ensures lasting digestive well-being.
– The active ingredients used are 100% natural, combined in a clever and sequential formulation guaranteeing the synergistic and effective action of the components,
– It is completely bioavailable and biocompatible.
– Resulting from the latest pharmaceutical innovations, the microgranules and their specific release properties ensure a sustained and targeted action of the active ingredients for a maximized efficiency.

Click here to discover the complex and know more about Activa Well Being Gastric

Sources:

^[1] Pandian RS1, Anuradha CV, Viswanathan P. Gastroprotective effect of fenugreek seeds (Trigonella foenum graecum) on experimental gastric ulcer in rats. J Ethnopharmacol. 2002 Aug;81(3):393-7.
^[2] H.M. Helmy. Study the Effect of Fenugreek Seeds on Gastric Ulcer in Experimental Rats. World Journal of Dairy & Food Sciences 6 (2): 152-158, 2011.
^[3] Y. Sauvaire, P. Petit, C. Broca, M. Manteghetti, Y. Baissac, J. Fernandez-Alavarez, R. Gross, M. Roye, A. Leconte, R. Gomis, G. Ribes ; 4-hydroxyisoleucine, Diabètes, 1998, 47, 206-210.
^[4] Jetté L, Harvey L, Eugeni K, Levens N., 4-Hydroxyisoleucine: a plant-derived treatment for metabolic syndrome, 2009 Apr;10(4):353-8.
^[5] Giselle Guginskia, Ana Paula Luizb, Morgana Duarte Silvab, Murilo Massarob, Daniel Fernandes Martinsb, Juliana Chavesa, Robson Willain Mattosc, Damaris Silveirac, Vânia M.M. Ferreirac, João Batista Calixtoa, Adair R.S. Santosa, Mechanisms involved in the antinociception caused by ethanolic extract obtained from the leaves of Melissa officinalis (lemon balm) in mice.
^[6] Mohamed T. Khayyal, Mona A. El-Ghazaly, Sanaa A. Kenawy, Mona Seif-El-Nasr, Laila G. Mahran, Yehia A. H. Kafafi, Samuel N. Okpanyic, Antiulcerogenic Effect of Some Gastrointestinally Acting Plant Extracts and their Combination, Arzneimittelforschung 2001; 51(7): 545-553.
^[7] Clare BA, Conroy RS, Spelman K. J Altern, The diuretic effect in human subjects of an extract of Taraxacum officinale folium over a single day. Complement Med. 2009 Aug;15(8):929-34.
^[8] Studies cited and summarised in: Kemper Kathi J., MD, MPH. Dandelion (Taraxacum officinalis) The Longwood Herbal Task Force and The Center for Holistic Pediatric Education and Research. www.longwoodherbal.org
^[9] Clare BA, Conroy RS, Spelman K. The diuretic effect in human subjects of an extract of Taraxacum officinale folium over a single day. J Altern Complement Med. 2009 Aug ;15(8) : 929-34.
¹⁰ Lima CF, Andrade PB, Seabra RM et al. The drinking of a Salvia officinalis infusion improves liver antioxidant status in mice and rats. J Ethnopharmacol. 2005;97:383-389.

EPA and DHA in Omega 3, what do they do?

The EPA & DHA are “anti-platelet aggregation”

When blood platelets stick together, they can form arterial plugs (thromboses) that prevent blood from flowing. This blood clot can detach and block a small vessel in the brain, resulting in a transient ischemic stroke. Omega 3 promote the production of nitric oxide which protects blood vessels.

Moreover, EPA and DHA are anti-atherogenic since they fight against the formation of fatty deposits⁽¹⁾.

Indeed, EPA inhibits the synthesis of thromboxane – prostaglandin promoting platelet adherence – and on the other hand, stimulates the production of prostacyclins that decrease platelet aggregation.

DHA & EPA help fight against oxidative stress
We know that oxidative stress plays a role in the formation of clots. By incorporating itself into the platelets’ membrane, EPA protects them against free radicals and thus reduces their aggregation. A 3-year study of 563 men with hyperlipidemia showed that supplementation with Omega 3 reduced the concentration of platelet adhesion molecules, thereby reducing the risk of atherosclerosis and stroke ⁽²⁾.

Moreover, in chronic heart failure (CHF), cardiomyocytes are disorganized and free radicals are produced in excess, exceeding the neutralizing capacities of enzymatic equipment. Daily supplementation with Omega-3 significantly increases the concentration of superoxide dismutase (SOD), a key enzyme in the fight against free radicals ⁽³⁾.

In conclusion, through a set of complex mechanisms, not yet fully clear, Omega 3 reduce triglyceridemia, platelet aggregation and regulate heart rate and contractility, thus protecting against cardiovascular risk.

Impact of DHA & EPA on the heart from childhood
Several studies have shown the relationship between blood DHA levels and blood pressure in healthy children. Children who are breastfed, either by breast milk or by milk supplemented with Omega 3 have a lower blood pressure at the age of 6-7 years⁽⁴⁾. More generally, the needs of a child between 3 and 9 years are 250 mg EPA + DHA and rise to 500 mg between 10 and 18 years, but the levels of these two omega-3 fatty acids are too low in the Western diet. Supplementation with DHA and EPA during pregnancy, lactation and childhood, therefore, plays an important role in cardiovascular development and function⁽⁵⁾.

What are optimum needs in DHA & EPA?
Although omega-3s have many virtues for the human body, they are still insufficiently consumed today, since our diet provides us with only 30% of the DRI (Dietary Reference Intakes).

After evaluating the French population’s daily intake of omega-3, the ANSES recommended: “the implementation of a policy aimed at increasing the level of omega-3 intake” ⁽⁶⁾.

The minimum physiological requirement for DHA and EPA was estimated by the ANSES to be 500 mg/day for an adult. Adults in France receive an average of 350mg of EPA + DHA per day for women and 420 mg/day for men ⁽⁷⁾. They are therefore below the 500 mg/day guideline. Supplementation of about 100 mg minimum is essential for good memory and optimal brain function.

Activa Human Structure Cardio is made from wild fish oil, rich in omega 3, certified Epax®, the quality label of fish oils. The EPAX® International Quality standard is the reference. EPAX® quality ensures the use of fish caught in ocean areas virgin of any industry to ensure optimum quality and purity, that is, optimum quality. It is analyzed for its content in heavy metals, pesticides or dioxin. EPAX® quality ensures quality controls at every stage of production, from raw materials to the finished product.

Meanwhile, before consuming a fish oil capsule make sure this is certified Epax® quality to guarantee a continuous supply of very high quality and high purity oil.

Sources:

[1] O’Keefe JH Jr & Harris WS: From Inuit to implantation : omega-3 fatty acids come of age. Mayo Clin. Proc. 2000 Jun;75(6):607-14.
[2] Smith BK. & Al.: Exercise plus n-3 fatty acids: additive effect on postprandial lipemia. Metabolism. 2004 Oct;53(10):1365-71.
[3] Mori TA & Woodman RJ: The independant effects of eicosapentaenoic acid and docosahexaenoic acid on cardiovasclar risk factors in humas.2006 Mar;9(2):95-104.
[4] Hjerkinn EM & Al.: Influence of long term intervention with dietary counseling, long chain n-3 fatty acid supplements, or both on circulation markers of endothelial activation in men with long-standing hyperlipidemia. Am. J. Nutr. 2005 Mar;81(3):583-9.
[5] Luostarinen, 1997
[6] Oméga-3. Afssa Février 2009 – www.afssa.fr
[7] EFSA. Scientific opinion – Labelling reference intake values for n-3 and n-6 polyunsaturated fatty acids. The EFSA Journal 1176, 1-11, 2009
Forsyth JS, Willatts P, Agostoni C, Bissenden J, Casaer P, Boehm G. Long chain polyunsaturated fatty acid supplementation in infant formula and blood pressure in later
childhood: follow up of a randomised controlled trial. Br Med J. 2003;326:953.
Koletzko B. Fats for brains. Eur J Clin Nutr 1992 ; 46 Suppl 1: S51-62.

Images Credit: Pixabay

Cholesterol and cardiovascular disease

Activa, a patented technology

Activa offers a unique and patented galenic innovation: Microgranules applied to phytotherapy.

The unique delivery system of microgranules, offers numerous benefits and advantages compared to classic galenic forms such as powders:

– Guarantee of bioavailability and therefore optimal efficiency,
– A patented biocompatible neutral nucleus and a semipermeable membrane ensuring the protection and release of 96% of the active ingredients
– Multi-particle shape offer an increased surface of exchanges
– Guarantee of a fast passage of the pylorus for a fast action
– Microgranules allow prolonged and controlled release of active ingredients, with a “delay” action
– Better consumer compliance and convenience of use:

• with a reduced dosage and better comfort by masking the taste and smell of some plant extracts
• Microgranules, gathered in a capsule, are particularly suitable for people suffering from swallowing difficulties or prone to “wrong path” swallowing since their membrane allows a good distribution of active ingredients even if they are mixed with a product such as yogurt, for example. Opening the capsules does not alter the effectiveness of the ingredients (except for “delayed” release formula), makes it easier to take and allows the dosage to be respected by people who have difficulty swallowing.

Activa complexes are designed taking into account the self-regulatory capacity of the organism. The active ingredients combined with this top-edge, unique and innovative technology of plant extracts microgranules, engage, encourage and support organic natural regulatory mechanisms by providing the necessary nutrients in a targeted way when they are needed the most and without side effects.

Galenic form: powder or microgranule?

The rate of release and bioavailability of an active ingredient depending on its galenic formulation may be modified by technological or formulation processes. This is why delayed-release forms are most often tablets or gastro-resistant capsules (capsules), releasing the active ingredient into the intestine instead of the stomach.

A capsule naturally contains an active part composed of powder or microgranules. Microgranules were initially associated with a particular function: gastro-resistance, prolonged release, etc. But the latest scientific advances and research on bioavailability have shown a clear preeminence of microgranules over powder in general.

Monitoring and controlling Bioavailability,
a technical expertise

According to the European Medicines Evaluation Agency (EMEA, Human guideline 2001), bioavailability is defined as the rate and extent to which the active substance or its active fraction is absorbed from its pharmaceutical formulation and becomes available at the site of action. It is the only pharmacokinetic variable that can be modified and improved because it does not depend only on biological factors. Indeed, by definition, when an active substance is administered intravenously, its bioavailability is 100%. However, if administered by other routes (e.g., oral), its bioavailability is generally lower and decreases (due to incomplete absorption by metabolic protection) or may vary from person to person.

Better control of bioavailability of herbal complexes allows:
– The integrity of the active substance without any degradation or “waste”
– Reproducible systemic exposures despite the variability between subjects. It must be understood that low bioavailability (e.g. 10%) cannot be compensated by simply multiplying the dose by 10 when the objective is to achieve an exposure corresponding to bioavailability of 100%
– No dose increase to properly expose all individuals and thus control interactions between active substances and avoid overexposure leading to side effects.

The speed of bioavailability is also essential because of its controls the shape of the plasma concentration curve, which can have a major influence on therapeutic and toxic effects.
It is also essential to know this speed of availability for formulations that have been designed precisely to control it (controlled or delayed release formulations): The Bioavailability.

Laboratoires Activa herbal supplements technology of microgranules offers a galenic form enabling an optimal gastroprotection and control release of the actives when they reach the point of absorption, thus giving optimal bioavailability of about 96%.

Biocompatibility,
the subtle balance to respect the body physiology

Biocompatibility defines the capacity of a substance designed to interact with a living organism without interfering, disrupting or modifying the later. Biocompatible is a term commonly used in the medical world to refer to medical implants or prosthetic materials used for humans and designed to be in harmonious interaction with the receiving body without creating a disturbance in its functions and physiology.

In the world of health supplements and medication, it applies to the capacity of the substances or active ingredients used, to be assimilated and/or active without creating any disturbance in the organism. This concept should be of prime focus in the research and development phase of any product. Making sure the formulation will fulfil its targeted function with total respect of the delicate physiology of the body.

This is made possible by taking into account the organism-environment where the active ingredients will be released, the targeted function to support, but also the possible interaction between the various composing substances, as well as the general overview of the human body as a complex system where every vital functions are interconnected. Targeting a specific area could affect the physiology of another.

Laboratories Activa herbal supplements blends, do not ever fight against a symptom but aim to strengthen the body’s natural self-regulation so that it recovers all its vitality through cellular stimulation and regulation. The regulation is performed by the body itself and therefore confer total biocompatibility, which limits the undesirable effects and any interaction between the different treatments in progress.

The body is then respected and will enable its cells to regulate the dysfunction, supported by the targeted action of the synergy of dry titrated extracts (the most active principles of a plant) offering the necessary ability to fight in order to maintain optimum vitality daily without supplementing them.

The 5 pillars of Phytovitality,
supporting cellular regulation

PhytoVitality uses the proven benefits of plants extracts combined with the advantages of microencapsulation technology to bring the best benefits and efficiency in herbal supplementation. This complete and comprehensive approach of wellness and human physiology aims at stimulating organic auto-regulation. It is developed using essential principles, pillars to ensure unique advantages of high-quality products with uncompromised quality, high efficacy and optimal results.

I – Selection of complementary active ingredients
Each active ingredient is selected for its known benefits but also for its synergistic potential when combined with others.
Advantages :
– Maximising synergy and increasing the potential of each plant
– Preventing antagonistic actions of active ingredients
– Developing unique blends of active ingredients

II – Quality first: ensuring consistency and safety

The high quality of the raw materials selected is the promise of uncompromised quality and guaranteed consistency using:
– Natural active ingredients, no GMOs or pesticides
– Dry titrated extracts
– High concentration of tracers

III – Patented blending protocols

IV – Global action

For the best chances of full recovery without returning symptoms, it is important to treat a condition and all its related manifestations. Within a system dysfunction, there are a few “issues” to address.
– The active ingredients are selected to work synergistically to address and treat each and every aspect of the dysfunction

Example: Addressing the whole aspects of Urinary Tract Infection

V – Bioavailable & Biocompatible
Objectives:
– Perfect assimilation without causing any side effect in the body.
– When addressing a specific “sphere” / zone, we make sure that other zones “systems” in the body are not affected and disrupted (biocompatibility)