{"id":3977,"date":"2018-11-16T05:23:01","date_gmt":"2018-11-16T04:23:01","guid":{"rendered":"https:\/\/www.laboratoiresactiva.com\/en\/?p=3977"},"modified":"2022-10-12T05:50:21","modified_gmt":"2022-10-12T03:50:21","slug":"melatonin-the-sleep-hormone","status":"publish","type":"post","link":"https:\/\/www.laboratoiresactiva.com\/en\/melatonin-the-sleep-hormone\/","title":{"rendered":"Melatonin, &#8220;The Sleep Hormone&#8221;"},"content":{"rendered":"<div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-1 nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"background-color: rgba(255,255,255,0);background-position: center center;background-repeat: no-repeat;padding-top:10px;padding-right:30px;padding-bottom:10px;padding-left:30px;margin-bottom: 0px;margin-top: 0px;border-width: 0px 0px 0px 0px;border-color:#eae9e9;border-style:solid;\" ><div class=\"fusion-builder-row fusion-row\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-0 fusion_builder_column_1_1 1_1 fusion-one-full fusion-column-first fusion-column-last\" style=\"margin-top:0px;margin-bottom:0px;\"><div class=\"fusion-column-wrapper fusion-flex-column-wrapper-legacy\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;background-color:#ffffff;padding: 50px 50px 30px 50px;\"><div class=\"fusion-column-content-centered\"><div class=\"fusion-column-content\"><style type=\"text\/css\"><\/style><div class=\"fusion-title title fusion-title-1 fusion-sep-none fusion-title-text fusion-title-size-one\" style=\"margin-top:0px;margin-right:0px;margin-bottom:31px;margin-left:0px;\"><h1 class=\"title-heading-left\" style=\"margin:0;\"><h2 class=\"entry-title\" style=\"text-align: center;\" data-fontsize=\"45\" data-lineheight=\"67\">Melatonin, \u201cThe Sleep Hormone\u201d<\/h2><\/h1><\/div><div class=\"imageframe-align-center\"><span class=\" fusion-imageframe imageframe-none imageframe-1 hover-type-none\"><img decoding=\"async\" width=\"800\" height=\"400\" title=\"5\" src=\"https:\/\/www.laboratoiresactiva.com\/en\/wp-content\/uploads\/2020\/01\/5.png\" class=\"img-responsive wp-image-3978\" srcset=\"https:\/\/www.laboratoiresactiva.com\/en\/wp-content\/uploads\/2020\/01\/5-200x100.png 200w, https:\/\/www.laboratoiresactiva.com\/en\/wp-content\/uploads\/2020\/01\/5-400x200.png 400w, https:\/\/www.laboratoiresactiva.com\/en\/wp-content\/uploads\/2020\/01\/5-600x300.png 600w, https:\/\/www.laboratoiresactiva.com\/en\/wp-content\/uploads\/2020\/01\/5.png 800w\" sizes=\"(max-width: 861px) 100vw, 800px\" \/><\/span><\/div><style type=\"text\/css\"><\/style><div class=\"fusion-title title fusion-title-2 fusion-sep-none fusion-title-text fusion-title-size-one\" style=\"margin-top:0px;margin-right:0px;margin-bottom:31px;margin-left:0px;\"><h1 class=\"title-heading-left\" style=\"margin:0;\"><\/h1><\/div><div class=\"fusion-text fusion-text-1\"><p style=\"text-align: justify;\">Melatonin, also called the \u201csleep hormone \u201d is produced by the pineal gland at dusk. Melatonin thus plays a fundamental role in regulating our body clock as is responsible for the sleep\/wake cycle. \u00a0The pineal gland is sensitive to light and production of melatonin will reduce in the morning to onset awakening. Taken in excess of 1 mg, it helps reduce the time it takes to fall asleep.<\/p>\n<p style=\"text-align: justify;\">Melatonin is widely known to help your body adjust to jet lag. When you travel through different time zones your pineal gland doesn\u2019t adjust straight away to the new dusk \u201ctime\u201d, delaying your onset of sleep. Tricking the body by giving it melatonin helps adapt to the new time zone until your body adjusts its circadian cycle.<\/p>\n<p style=\"text-align: justify;\">Not only inducing sleep, melatonin is known to also improve the quality of your sleep during periods of stress. Indeed the overall studies published since 2001 show it influences the time needed to fall asleep.<\/p>\n<p style=\"text-align: justify;\">Melatonin works well to treat delayed sleep-phase disorder. This problem is related to a disturbance of the circadian rhythm. Sufferers fall asleep between 3 am to 6 am and wake up around midday \u00a0to 3 pm.<\/p>\n<p style=\"text-align: justify;\">Researchers have found that people with certain health problems had melatonin levels below average. They have also made a connection with the consumption of melatonin during the day that could help reduce some psychological stress-related disorders such as depression, anxiety and agitation. Researchers conducted a study taking into account stress as a major contributing factor to depression and demonstrating the importance of resynchronization of circadian rhythms for effective treatment of depression. This study highlighted the melatonin potential as an antidepressant.<\/p>\n<p style=\"text-align: justify;\">Finally, it has also been shown to help people suffering from migraine, irritable bowel syndrome \u00a0and fibromyalgia, as it can reduce chronic pain.<\/p>\n<p style=\"text-align: justify;\">Consumption of melatonin at a reasonable dose is relatively safe, however it should be used with caution and moderation and restricted to short term use. Prolonged use could have some physiological side effect on your body\u2019s natural production of melatonin. Your pineal gland could become lazy or stop its production if you substitute it with synthetic melatonin.<\/p>\n<p><strong><span style=\"font-size: 14px;\"><em><strong>Sources<\/strong><\/em><\/span><\/strong><\/p>\n<ul>\n<li><span style=\"font-size: 14px;\"><em>Ballard CG, O\u2019Brien JT, et al. Aromatherapy as a safe and effective treatment for the management of agitation in severe dementia: the results of a double-blind, placebo-controlled trial with Melissa.<\/em><\/span><\/li>\n<li><span style=\"font-size: 14px;\"><em>Amsterdam JD1, Li Y, Soeller I, Rockwell K, Mao JJ, Shults J., A randomized, double-blind, placebo-controlled trial of oral Matricaria recutita (chamomile) extract therapy for generalized anxiety disorder. Depression Research Unit, University Science Center.<\/em><\/span><\/li>\n<li><span style=\"font-size: 14px;\"><em>Hanus M1, Lafon J, Mathieu M, Double-blind, randomised, placebo-controlled study to evaluate the efficacy and safety of a fixed<\/em><\/span><\/li>\n<li><span style=\"font-size: 14px;\"><em>combination containing two plant extracts (Crataegus oxyacantha and Eschscholtzia californica) and magnesium in mild-to-moderate anxiety disorders.<\/em><\/span><\/li>\n<li><span style=\"font-size: 14px;\"><em>\u00c9tude sur l\u2019Eschscholtzia californica men\u00e9e par l\u2019\u00e9quipe du Laboratoire de Pharmacognosie de l\u2019universit\u00e9 de Metz .<\/em><\/span><\/li>\n<li><span style=\"font-size: 14px;\"><em>Brzezinski A, Vangel MG, et al. Effects of exogenous melatonin on sleep: a meta-analysis. Sleep Med Rev. 2005 Feb;9(1):41-50.10. Buscemi N, Vandermeer B, et al. The efficacy and safety of exogenous melatonin for primary sleep disorders. A meta-analysis. J Gen Intern Med. 2005 Dec;20(12):1151-8.<\/em><\/span><\/li>\n<li><span style=\"font-size: 14px;\"><em>Jansen S, Forbes D, Duncan V, Morgan D, Malouf R. Melatonin for the treatment of dementia.Cochrane Database Syst Rev. 2011;(1):CD003802. R\u00e9sum\u00e9 www2.cochrane.org<\/em><\/span><\/li>\n<li><span style=\"font-size: 14px;\"><em>Detanico BC 1 , Piato AL , Freitas JJ , Lhullier FL , Hidalgo MP , Caumo W , Elisabetsky E .Antidepressant-like effects of melatonin in the mouse chronic mild stress model. Eur J Pharmacol 2009 1 avril; 607 (1-3): 121-5. doi: 10.1016 \/ j.ejphar.2009.02.037. Epub 2009 le 26 f\u00e9vrier.<\/em><\/span><\/li>\n<li><span style=\"font-size: 14px;\"><em>The use of exogenous melatonin in delayed sleep phase disorder: a meta-analysis. van Geijlswijk IM, Korzilius HP, Smits MG. Sleep. 2010 Dec;33(12):1605-14.<\/em><\/span><\/li>\n<li><span style=\"font-size: 14px;\"><em>Effect of melatonin administration on sleep, behavioral disorders and hypnotic drug discontinuation in the elderly: a randomized, double-blind, placebo-controlled study. Garz\u00f3n C, Guerrero JM, et al. Aging Clin Exp Res. 2009 Feb;21(1):38-42.<\/em><\/span><\/li>\n<li><span style=\"font-size: 14px;\"><em>Mcllwain H. Adenosine in neurohumoral \u00b7 and regulatory roles in the brain. ln : Genazzani E, Herken H, eds. Central Nervous System \u2013 Studies on metabolic regulation and Junction. Berlin : Springer Verlag, 1973 : 3-11.<\/em><\/span><\/li>\n<li><span style=\"font-size: 14px;\"><em>Harms HH, Wardeh G, Mulder AH. Effects of adenosine on depolarization induced release of various radiolabeled neurotransmitters from slices of rat corpus striatum. Neuroplw.muJCology 1979 ; 18 : 577-80.<\/em><\/span><\/li>\n<li><span style=\"font-size: 14px;\"><em>Harms HH, Wardeh G, Mulder AH. Effects of adenosine on depolarization induced release of various radiolabeled neurotransmitters from slices of rat corpus striatum. Neuroplw.muJCology. 1979 ; 18 : 577-80.<\/em><\/span><\/li>\n<li><span style=\"font-size: 14px;\"><em>Berne RM, Rubio R, Curnish RR. Release of adenosine from ischemie brain. Effect of cerebral vascular resistance and incorporation into cerebral adenine nucleotides. Circ Res 1974- ; 35 : 262-71.<\/em><\/span><\/li>\n<li><span style=\"font-size: 14px;\"><em>Maitre M, Ciesielski L, Lehmann A, Kempf E, Mandel P. Protective effect of adenosine and nicotinamide against audiogenic seizure. Biochem Plw.muJCol 1974 ; 23 : 2807-16.<\/em><\/span><\/li>\n<li><span style=\"font-size: 14px;\"><em>Jones P, Bachelard HS, Studies on amino acid metabolism in the brain using 15N-labeled precursors.<\/em><\/span><\/li>\n<\/ul>\n<p><span style=\"font-size: 14px;\"><em>\u00a0<\/em><\/span><\/p>\n<p><strong><span style=\"font-size: 14px;\"><em><strong>Images Credit: DepositPhotos<\/strong><\/em><\/span><\/strong><\/p>\n<\/div><\/div><\/div><div class=\"fusion-clearfix\"><\/div><\/div><\/div><\/div><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":6,"featured_media":3978,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[1,59],"tags":[107,106],"class_list":["post-3977","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-all-articles","category-sleep-stress","tag-serenity","tag-sleep-stress"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.6 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Melatonin, &quot;The Sleep Hormone&quot; - Laboratoires Activa<\/title>\n<meta name=\"description\" content=\"What is Melatonin and how can it affect the circadiam rhythm and the quality of your sleep? 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