{"id":3980,"date":"2018-09-24T08:37:10","date_gmt":"2018-09-24T06:37:10","guid":{"rendered":"https:\/\/www.laboratoiresactiva.com\/en\/?p=3980"},"modified":"2022-10-12T05:54:11","modified_gmt":"2022-10-12T03:54:11","slug":"prebiotics-and-probiotics-the-bodyguards-of-your-immunity","status":"publish","type":"post","link":"https:\/\/www.laboratoiresactiva.com\/en\/prebiotics-and-probiotics-the-bodyguards-of-your-immunity\/","title":{"rendered":"Why Prebiotics & Probiotics together?"},"content":{"rendered":"

Why Prebiotics & Probiotics together?<\/h2>\n<\/div>
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The role of the intestine is not limited to the assimilation of nutrients and the elimination of waste, but it extends to the protection of the whole body. Indeed, it provides an effective preservation against bacteria, viruses, toxic and allergens in the intestinal lumen, through three defensive lines: the intestinal flora, intestinal epithelium, and the intestinal immune system.<\/span><\/p>\n

The role of the Intestinal Flora
\n<\/span><\/strong>Our intestines produce 70 to 85% of the immune cells of the organism and host 100 000 billion bacteria from 400 different species which compose the intestinal flora.
\nAmong these bacteria, most are harmless or beneficial for the body. Under normal circumstances, other, potentially pathogenic, are too few to have an adverse effect. Indeed, by producing lactic acid, the \u201cgood\u201d bacteria make the intestinal environment unfavorable to the development of pathogenic bacteria.<\/span><\/p>\n

The bacteria of the intestinal flora feed on derived food unused by the body (fibers, cartilage, etc.) and play an important role:
\n<\/span>\u2013\u00a0<\/span>Digestion:<\/strong>\u00a0The flora completes the food digestion by the fermentation process. It also participates to the digestive motility, in other words, the intestinal transit.
\n\u2013\u00a0<\/span>Assimilation<\/strong>\u00a0of nutrients.
\n\u2013\u00a0<\/span>Elimination<\/strong>\u00a0of waste: cholesterol uptake, elimination of toxic as ammonia, nitrites, etc.
\n\u2013\u00a0<\/span>Barrier<\/strong>\u00a0against infection: the bacteria of the intestinal flora stimulate macrophages and lymphocytes; these cells play a major role in the general immunity of our body.
\nBut, any aggression to the intestinal flora can affect its balance and allow harmful bacteria to grow: stress, overuse of medication, unhealthy diet and\/or low in fiber, infections, diseases, or taking antibiotics.<\/span><\/p>\n

The enteric nervous system:
\n<\/span><\/strong>Studies conducted by Michael D. Gershon, a researcher at Columbia University, US, have shown that the enteric nervous system (intestinal), called also the second brains contains over\u00a0100 million neurons\u00a0and secretes at least\u00a020 neurotransmitters\u00a0identical to those found in the brain. It participates in the\u00a0management of our emotions\u00a0and it is involved in pain control and regulation of thermoregulation, food, and sexual behavior, sleep-wake cycle, pain and anxiety.
\n<\/span>In summary, our intestine is a key element for our health and mood. It is, therefore, important to maintain a rich and balanced intestinal flora.<\/p>\n

Choose high-quality Probiotics and Prebiotics for a natural, fast and gentle action:
\n<\/span><\/strong>To ensure the good balance of our intestinal flora, nutritional supplements such as Probiotics and Prebiotics are particularly recommended.
\n<\/span>Probiotics are micro-organisms ingested alive that colonize our digestive tract and allow friendly bacteria residing in the intestinal flora, to grow and \u201cget over\u201d the pathogenic bacteria. They help the intestinal flora to fulfill better its assimilation, digestion, and elimination1 functions. They also have a beneficial effect on the stimulation of the natural defenses, the state of stress and anxiety.<\/p>\n

Prebiotics are nutrients that resist to the stages of digestion and intestinal absorption and are intended to feed certain bacteria. They favor the growth of beneficial bacteria over that of harmful ones.<\/p>\n

The scientific observations show the beneficial effect of the Pro and Prebiotics combination and consider its superior action to those with the Probiotics only.<\/p>\n

Four Probiotics to restore and balance the intestinal flora<\/span><\/strong><\/span><\/p>\n

Lactobacillus Rhamnosus
\n<\/span><\/u><\/strong>This bacterium has been the subject of considerable research. It is often used in dairy products in Finland and the US, where its virtues to enhance immunity are sought[2]<\/sup>:
\n\u2013 Lactobacillus rhamnosus protects against\u00a0acute diarrhea[3]<\/sup> caused by viral gastroenteritis.
\n\u2013 Associated to Bifidobacterium longum, it proves a great efficiency to prevent Tousista \u2013 shown by numerous clinical[4]<\/sup> trials
\n\u2013 Associated with Bifidobacterium longum, it acts on\u00a0the eradication of infections\u00a0by the helical pylori \u2013 this latter being the cause of many\u00a0gastritis and most peptic ulcers. In 2009, two meta-analyses have proven the effectiveness of probiotics to help cure this infection and mitigate its adverse effects[5,6]<\/sup>.
\n\u2013 It improves the condition of people suffering from\u00a0irritable bowel\u00a0syndrome by alleviating pain, flatulence, bloating and regulating\u00a0intestinal[7]<\/sup> transit.
\n<\/strong>\u2013 Lactobacillus rhamnosus reduces the protective layer in the intestines, especially in cases of\u00a0alcohol[8]<\/sup>\u00a0<\/sup>problems.
\n\u2013 It avoids\u00a0complications\u00a0due to taking an\u00a0antibiotic[9]<\/sup> treatment.
\n\u2013 It has a powerful action on the\u00a0vaginal infections, by intervening in the vaginal flora balance[10]<\/sup>.
\n\u2013 Lactobacillus rhamnosus has significant impacts on\u00a0anxiety and obesity\u00a0by slowing the release of corticotropin-releasing hormones (CRH) that control the activity of the hypothalamic-pituitary-adrena axis[11]<\/sup>.<\/p>\n

Bifidobacterium Longum
\n<\/span><\/u><\/strong>Among the 400 species of bacteria of the intestinal flora, Bifidobacterium longum is one of the most common and most studied. It would constitute more than 95% of the intestinal flora of breastfed[12]<\/sup> infants, which would explain their greater resistance to infection.<\/p>\n

Among its actions, it has been verified that:
\n\u2013 Associated with Lactobacillus rhamnosus, she proved great effectiveness to prevent the \u201cturista\u201d (see previous paragraph).
\n\u2013 Associated with Lactobacillus rhamnosus, it acts on the\u00a0eradication of infections\u00a0by the helico pylori (see previous paragraph).
\n\u2013 Bifidobacterium longum improves the condition of people suffering from\u00a0irritable bowel syndrome[13]<\/sup>.
\n\u2013 It relieves the symptoms of\u00a0lactose intolerance[14]<\/sup>.
\n\u2013 It calms the inflammation associated with\u00a0Crohn\u2019s disease\u00a0or\u00a0colitis.
\n\u2013 It prevents relapses of\u00a0ulcerative colitis\u00a0by extending remissions[15]<\/sup>.
\n\u2013 Lactic acid produced by Bifidobacterium longum has\u00a0anti-carcinogenic\u00a0and anti-mutagenic properties. Studies have proven its effects on tumor[16]<\/sup>.<\/p>\n

Lactobacillus Acidophilus
\n<\/span><\/u><\/strong>This bacterium was isolated, in 1900, in the faeces of infants and named Bacillus acidophilus because of its remarkable tolerance to acidity.<\/p>\n

It has many properties:
\n\u2013 A proven effectiveness in\u00a0preventing diarrhea caused\u00a0by antibiotics, in combination with Bifidobacterium longum.
\n\u2013 Lactobacillus acidiphilus specifically attenuates intestinal problems\u00a0caused by anxiety[17]<\/sup>.
\n<\/strong>\u2013 It has been proven it has an antagonistic activity\u00a0against pathogens\u00a0of food products such as Staphylococcus aureus, Salmonella typhimurium, Escherichia coli and Clostridium perfringens[18]<\/sup>.
\n\u2013 It is known to have the ability to\u00a0metabolize lactose\u00a0in the small intestine and thus facilitate its\u00a0digestion[19]<\/sup>.
\n\u2013 It is\u00a0anti-carcinogenic. An experiment conducted in rats shows a lower incidence of colon cancer after a period of 20 weeks, with the administration of the bacteria[20]<\/sup>.
\n\u2013 It easily adheres to the wall of the intestine, which\u00a0facilitates its implantation\u00a0in a\u00a0cure of probiotics[21]<\/sup>.
\n\u2013 Finally, Bacillus acidophilus can treat or prevent vaginal infections. In 2009, researchers have compared the effectiveness of various treatments against\u00a0bacterial vaginosis, one of the most common causes of\u00a0vaginitis[22]<\/sup>. They concluded that the local use of lactobacilli is\u00a0more effective than antibiotics\u00a0prescribed orally (clindamycin, metronidazole).<\/p>\n

Bifidobacterium Infantis
\n<\/span><\/u><\/strong>This strain of bacteria is acquired naturally during childbirth and then with breastfeeding[23]<\/sup>, which would explain the greater resistance to infections in breastfed infants[24]<\/sup>.
\nIrritable bowel syndrome is accompanied by a significant reduction in the amount of intraluminal bifidobacteria, with consequences such as colic gas production and impaired motility of the intestinal tract.
\nIngesting a probiotic complement of the Bifidobacterium Infantis strain allows to re-seed good bacteria and to act effectively and without side effects for:
\n– Reduce pain due to irritable bowel syndrome. Indeed, it has been demonstrated, for example, that a complex of Bifidobacterium Infantis and Longum is associated with better control of intestinal pain and improves quality of life compared to placebo in children with SCI[25]<\/sup>
\n– Decrease \u201cbloating\u201d which is particularly difficult to treat and often categorized as the most intrusive symptom by those affected by SCI[26]<\/sup>,
\n– Normalize intestinal transit and cause overall relief in patients with SCI,
\n– Act on the psychological factors of the SCI: Bifidobacterium Infantis is considered as a \u201cpsychobiotic\u201d, with anti-inflammatory actions and a real ability to reduce the activity of the hypothalamic-pituitary-adrenal axis which maintains the capacity of the organism to respond to acute and prolonged stressors. Results of large-scale placebo-controlled studies are expected[27]<\/sup>.<\/p>\n

Two Prebiotics to reinforce the action of the Probiotics<\/span><\/strong><\/span><\/p>\n

Fructo Oligo Saccharides (FOS)
\n<\/span><\/u><\/strong>Prebiotics are non-assimilable carbohydrate by the body whose ingestion induces major changes in the intestinal flora, characterized by an increase in colonies of bifidobacteria and a decrease of those pathogenic bacteria.
\nThe FOS are short-chain carbohydrates with these virtues:
\n\u2013 They are immunomodulators: by increasing the colonies of bifidobacteria[28]<\/sup>, they allow the activation of lymphocytes and macrophages, the production of antibodies (sIgA) and finally increase the resistance to infections by pathogenic organisms.\u00a0They, therefore, maintain the intestinal immune system\u00a0(IBS).
\n\u2013 They act on the\u00a0stimulation of the short-chain fatty acids\u00a0(SCFA) synthesis: the water content in the colonic contents being increased, which eventually increases stool weight and softens consistency[29]<\/sup>.
\n\u2013 They induce a decrease in the pH of the colon,\u00a0enhance the intestinal absorption\u00a0of certain minerals, such as calcium and magnesium, and of certain substances, such as isoflavones, acting on\u00a0bone[30]<\/sup>mineral density.
\n\u2013 They limit the formation of carcinogens. Prebiotics can also prevent degradation of the genistein known for its\u00a0anti-cancer[32]<\/sup> effects.
\n\u2013 Finally, the FOS are relevant for the\u00a0infant\u2019s nutrition and\u00a0young children, in the absence or after the breastfeeding interruption.<\/p>\n

Taking Prebiotics as a supplement, in the form of Fructooligosaccharides, therefore provides\u00a0real health benefits, well beyond actions on digestive discomfort.<\/p>\n

Ribose
\n<\/span><\/u><\/strong>Ribose is a sugar useful to all living organisms. It plays three major roles:
\n\u2013 It is a component of adenosine triphosphate (ATP), the fuel of cell that meets\u00a0the body\u2019s energy needs.
\n\u2013 It has an action on the UTP (Uridine triphosphate): a compound that provides energy, helps the\u00a0muscle recovery and promotes the synthesis of glycogen.
\n\u2013 It enables the production of ribonucleic acid (RNA) for the transcription of the genetic[33]<\/sup> code.<\/p>\n

Ribose is therefore particularly important to\u00a0stimulate all the body\u00a0and reinforce the bacteria in the intestinal flora.
\n– It is composed of a studied mixture of three different Probiotics for further action and a full and rapid colonization of the intestine,
\n– To these Probiotics are associated two Prebiotics to reinforce their action, this complex contains strains recognized for their effectiveness and their complementary action,
\n– It reinforces the immune system,
\n– It improves the transit
\n– It restores the intestinal flora,
\n– It reduces the recurrence of vaginal mycoses,
\n– It helps to prevent the \u201cturista\u201d 15 days to 1 month before the trip,
\n– It avoids the undesirable effects of a long antibiotic therapy,
\n– The excellent tolerance achieved through the synergy of these components allows being used in the long term without side effects,
\n– It works by \u201cSustained release\u201d to pass the gastric barrier,
\n– It is made from 100% natural active, with a \u201csmart\u201d formulation for a synergistic and effective action of the components,
\n– It is completely bioavailable,
\n– Biocompatible, it respects the body and acts in depth on our vitality.<\/p>\n

Sources:
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\n<\/em>[2] \u00a0Doctissimo.fr website accessed September 11, 2014 \u00ab Il y a probiotiques et probiotiques \u00bb
\n<\/em>[3] Szajewska H, Mrukowicz JZ. Probiotics in the treatment and prevention of acute infectious diarrhea in infants and children: a systematic review of published randomized, double-blind, placebo-controlled trials. J Pediatr Gastroenterol Nutr. 2001 Oct;33 Suppl 2:S17-25.
\n<\/em>[4] McFarland LV. Meta-analysis of probiotics for the prevention of traveler\u2019s diarrhea. Travel Med Infect Dis. 2007 Mar;5(2):97-105. Epub 2005 Dec 5.
\n<\/em>[5] Sachdeva A, Nagpal J. Effect of fermented milk-based probiotic preparations on Helicobacter pylori eradication: a systematic review and meta-analysis of randomized-controlled trials. Eur J Gastroenterol Hepatol. 2009 Jan;21(1):45-53.
\n<\/em>[6] Zou J, Dong J, Yu X. Meta-analysis: Lactobacillus containing quadruple t! herapy versus standard triple first-line therapy for Helicobacter pylori eradication. Helicobacter. 2009 Oct;14(5):97-107.
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\n<\/em>[8] Wang, Y.; Liu, Y.; Sidhu, A.; Ma, Z.; McClain, C.; Feng, W. Lactobacillus rhamnosus GG culture supernatant ameliorates acute alcohol-induced intestinal permeability and liver injury. Am J Physiol Gastrointest Liver Physiol 303 (1): G32\u201341. doi:10.1152\/ajpgi.00024.2012. PMID 22538402.\u00a0Forsyth, CB.; Farhadi, A.; Jakate, SM.; Tang, Y.; Shaikh, M.; Keshavarzian, A. (Mar 2009). Lactobacillus GG treatment ameliorates alcohol-induced intestinal oxidative stress, gut leakiness, and liver injury in a rat model of alcoholic steatohepatitis. Alcohol 43 (2): 163\u201372. doi:10.1016\/j.alcohol.2008.12.009. PMID 19251117.
\n<\/em>[9] McFarland LV. Meta-analysis of probiotics for the prevention of antibiotic associated diarrhea and the treatment of Clostridium difficile disease. Am J Gastroenterol. 2006 Apr;101(4):812-22. http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/16635227<\/a>
\n<\/em>[10] Oduyebo OO, Anorlu RI, Ogunsola FT. The effects of antimicrobial therapy on bacterial vaginosis in non-pregnant women. Cochrane Database Syst Rev. 2009 Jul 8;(3):CD006055. Revi! ew. http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19588379<\/a>
\n<\/em>[11] Alison C Bested, Alan C Logan, Eva M Selhub. Intestinal microbiota, probiotics and mental health: from Metchnikoff to modern advances: part III \u2013 convergence toward clinical trials. Gut Pathog. 2013; 5: 4. Published online 2013 March 16. doi: 10.1186\/1757-4749-5-4 http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3605358\/<\/a>
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\n<\/em>[13] Nikfar S, Rahimi R, et al. Efficacy of probiotics in irritable bowel syndrome: a meta-analysis of randomized, controlled trials. Dis Colon Rectum. 2008 Dec;51(12):1775-80. Epub 2008 May 9.
\n<\/em>[14]\u00a0He T1<\/sup>, Priebe MG, Zhong Y, Huang C, Harmsen HJ, Raangs GC, Antoine JM, Welling GW, Vonk RJ. Effects of yogurt and bifidobacteria supplementation on the colonic microbiota in lactose-intolerant subjects. J Appl Microbiol. 2008 Feb;104(2):595-604. Epub 2007 Oct 9. http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17927751<\/a>.
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\n<\/em>[19] R G Montes, Effect of milks inoculated with Lactobacillus acidophilus or a yogurt starter culture in lactose-maldigesting children, Journal of dairy science, vol. 78, no 8,\u200e 1995-08, p. 1657-1664 (ISSN 0022-0302, DOI 10.3168\/jds.S0022-0302(95)76790-X)
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\n<\/em>[23] Mark A. Underwood, J. Bruce German, Carlito B. Lebrilla, David A. Mills. Bifidobacterium longum subspecies infantis: champion colonizer of the infant gut. Pediatr Res. Author manuscript; available in PMC 2015 March 5. \u00c9tude ici
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\n<\/em>[33] Masantenaturelle.com website accessed September 11, 2014, une seconde vie gr\u00e2ce au Ribose<\/em><\/span><\/p>\n

Images Credit: DepositPhotos<\/strong><\/em><\/strong><\/span><\/p>\n<\/div>

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