Curcuma longa, also known as curcumin, is a powerful natural anti-inflammatory agent contained in turmeric, known as the natural inflammatory reference compound for the treatment of joints and arthritic pain. Most natural supplements addressing joint conditions contain curcumin alongside glucosamine and chondroitin. By reducing inflammation, curcumin participates in the inhibition of one of the causes of cartilage destruction. However, turmeric-based products have a very low bioavailability rate as it is very poorly assimilated by the organism (maximum of 1%). To be effective curcumin must be taken at the minimum dose of 1,200 mg a day. At a lower dose, it acts as an antioxidant on the digestive sphere but has no anti-inflammatory effect.
Turmeric Super Extract
TSE, Turmeric Super Extract, is an extract obtained from Curcuma Longa L. standardized and stable in pure curcumin form combining the fast analgesic action of an NSAID with the safety of a natural product.
The innovative and unique aspect of TSE lies in the technique of extraction and blending curcumin with food glucose to improve and guarantee the assimilation of this active principle, obtaining a bio equivalent dosage of 1200 mg of free curcumins for 32 mg of TSE and consequently its anti-inflammatory effectiveness and bioavailability.
Comparative studies with NSAID have demonstrated that TSE is a strong inhibitor of PGE2 (Prostaglandin E2); a powerful inflammatory mediator involved in joint and osteoarthritis pain as well as a potent inhibitor of COX2 (cyclooxygenase-2): involved in osteoarthritis inflammation.
TSE is a potent inhibitor of the pro-inflammatory cytokines IL1, IL6 and IL8 (very powerful inflammatory mediators involved in inflammation and cartilage damage), and of NO (potent mediator involved in the destruction of chondrocytes, i.e. cartilage cells).
TSE does not inhibit COX1 (cyclooxygenase-1) and has no cytotoxicity, thus preserving the integrity of the gastrointestinal mucosa at the opposite of most NSAID. It is described in literature as having anti-ulcerogenic properties, which supports its long-term use.
These results have been scientifically demonstrated at the University Hospital Center of Lièges – Belgium (UROC), and other University Hospital Centers around the world, confirming the remarkable effectiveness and safety of use of the TSE extract.
– TSE inhibits joint and osteoarthritis pain very quickly (equivalent to NSAID)
– TSE is the only current treatment available that can also slow down one of the causes of osteoarthritis progression
– The excellent tolerance of TSE allows long-term use in the treatment and prevention of osteoarthritis, unlike NSAIDs.
Laboratoires Activa uses TSE in its Well Being Joint formula, designed to fight inflammation and cartilage degradation. The microgranule technology allows gastro-protection of the active ingredients for optimal bio-availability as well as a controlled release over an extended period of 8 hours.
Combined with Harpagophytum, Chondroitin, Glucosamine, the blend’s synergy increases ingredients potency, effectiveness, and speed of action.
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